Micromass Quattro Micro

Now available a used fully serviced and refurbished Micromass Quattro Micro including installation and training (*excludes MS Workstation and Alliance HPLC - both available at additional costs).

The Micromass Quattro micro API incorporates the finest high precision tandem quadrupole mass analyser technology in only 390mm of linear bench space and has a m/z range of 2-2000 as standard.

This system enables you to reach lower detection limits and increase sample throughput for all of your quantitative applications: ADME screening, food safety, environmental monitoring, clinical, bioavailability, and more.

  • Overview
  • Specifications
  • Why purchase used refurbished
    mass specs from KRSS
  • Why MS/MS?
  • Find Out More

Overview

The Micromass Quattro micro API is a step change advance over the classic "triple quadropole" concept. The traditional quadropole collision cell is replaced with a hexapole for advance ion containment and transmission. Hexapole technology used in conjunction with proprietary ion counting and threshold software, delivers superior sensitivity and enhanced resolution for precursor ion scanning experiments.

The high performance analyser is completed with an optically coupled, low noise/high gain orthologonal detector that approaches 100% efficiency for the detection of single ions. In this proprietary system the conventional electron multiplier has been suspended by a photomultiplier with a 10 year lifetime - simultaneously maximising sensitivity and minimising the cost of ownership.

The Astmospheric Pressure Ionisation (API) source features patented Z-SPRAY inlet technology for LC-MS-MS. The dual orthoganol geometry of ZSPRAY enables prolonged LC-MS-MS anaylsis of samples in complex biological or environmental matrices. ZSPRAY can even tolerate involatile buffers - saving time and money in HPLC method redevelopment. ZSPRAY is the only API interface available with an in-source isolation valve allowing the sampling cone to be rapidly removed for routine cleaning without breaking the vacuum - maximising up time. The inlet probe is mounted vertically for maximum space saving.

  • Accurate, reproducible chromatographic peak area measurement
  • Robust ZSpray™ atmospheric pressure ionization interface.
  • Versatile range of ionization options.
  • Multimode capability in a single run.
  • Automated instrument optimization and quantitative method development tools.
  • Dedicated application managers for your specialised analytical requirements.
  • Small footprint (390mm x 587 x 810mm) that sits easily on your benchtop

Compound identity confirmation can be achieved with MS/MS using this instrument in ion scan mode. With this mode, product ions are generated and detected for a specified precursor ion. The precursor and product ions, along with their ion ratios, can be used to confirm the identity of a compound.

Specific classes of compounds can be detected with MS/MS using the precursor ion or neutral loss mode. By detecting a specific product ion (precursor ion mode) or charged fragments resulting from a neutral loss (neutral loss mode), you can classify a compound of interest. These modes are helpful for monitoring classes of compounds like glycosylated peptides, glucuronide conjugates and aliphatic hydrocarbons.

The Quattro micro API Mass Analyzer
Using a tandem quadrupole mass analyzer with a hexapole collision cell, the Quattro micro API provides molecular weight, structural information, and quantitative data for a wide variety of analytes. Powerful and intelligent data acquisition allows you to collect the additional information required for your application.

Automated analysis of complex samples is enabled using Data Directed Analysis (DDA). In automated LC-DDA-MS analyses, the Quattro micro API Mass Analyzer continuously records ’survey’ (typically MS) spectra throughout a chromatographic run to dynamically identify candidates for MS/MS analysis. Ions shortlisted for MS/MS analysis can be compared with a list of known background ions (such as phthalates) to exclude redundant analyses. When a component of interest elutes, the analyzer switches from MS to MS/MS mode. Simultaneously, the system selects collision energy values for each targeted precursor ion and records a product ion spectrum. After the MS/MS analysis is completed, the system returns to the selected survey mode to hunt for the next candidate. The most commonly used survey mode is the full scan MS. Precursor ions that have been selected and analyzed may be dynamically appended to the exclusion list to prevent duplicate analyses.

Productivity through integration
Regardless of your application- pharmaceutical characterization, ADME-tox studies, impurity identification, forensic analysis or environmental contaminant quantification- Waters Mass Spectrometry Systems incorporating the Quattro micro API Mass Analyzer provide intelligent and productive solutions to your laboratory’s needs.


 

Specifications

  • Acquisition rates up to 5000 amu/sec
  • 2040 amu upper mass limit.
  • Verticaly mounted liquid inlet probes to minimise tube length and peak dispersion.
  • Software-controlled, integrated syringe pump for easy calibration, tuning and sample infusion.
  • Software-controlled divert valve/manual injection valve.
  • Edwards E2M28 Rotary Pump.

Why purchase used refurbished
mass specs from KRSS

KRSS Ltd offer high quality pre-owned Mass Spec, LCMS, GCMS, HPLC and GC systems allowing affordable entry into a rapidly developing market.

All KRSS instruments are thoroughly inspected by manufacturer trained engineers (including all components and parts), cleaned and decontaminated, completely refurbished (defective parts and components are replaced with genuine parts), serviced and bench tested to ensure the equipment meets the manufacturers original specifications - this guarantees quality, performance and reliability at a fraction of the OEM costs.

With over 50 instruments in stock, covering all major manufacturers KRSS has systems for a variety of application requirements. All instruments are supplied with a comprehensive warranty and optional service contracts to ensure trouble free operation.

 

Why MS/MS?

Tandem mass spectrometry, or MS/MS, is quickly becoming the preferred form of mass analysis in many high throughput analytical laboratories. Why? Because many single quadrupole MS users are saying:

If only I could obtain better limits of detection and quantification
Multiple Reaction Monitoring (MRM) with tandem MS provides exceptionally clean product (fragment) ion chromatograms for quantification. By selectively detecting a product ion of interest from a specified precursor ion, the signal-to-noice (s/n) ratio is optimized, thus lowering limits of detection(LOD). This mode is especially useful for the rapid screening of complex samples where analytes of interest are known.

I wish I could confirm the identity of this compound
Compound identity confirmation can be achieved with MS/MS using the product ion scan mode. With this mode, product ions are generated and detected for a specified precursor ion. The precursor and product ions, along with their ion ratios, can be used to confirm the identity of a compound.

I wonder if these compounds are related
Specific classes of compounds can be detected with MS/MS using the precursor ion or neutral loss mode. By detecting a specific product ion (precursor ion mode) or charged fragments resulting from a neutral loss (neutral loss mode), you can classify a compound of interest. These modes are helpful for monitoring classes of compounds like glycosylated peptides, glucuronide conjugates and aliphatic hydrocarbons.

Demo

 
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